| R | Player | Match | Runs | 4s |
|---|---|---|---|---|
| 1 |  Sachin Tendulkar MI | 15 | 618 | 86 |
| 2 |  Jacques Kallis RCB | 16 | 572 | 67 |
| 3 |  Mahela Jayawardene PBKS | 13 | 439 | 55 |
| 4 |  Kumar Sangakkara PBKS | 13 | 357 | 47 |
| 5 |  Virender Sehwag PBKS | 14 | 356 | 47 |
| 6 |  Michael Lumb DCH | 11 | 278 | 45 |
| 7 |  Suresh Raina CSK | 16 | 520 | 45 |
| 8 |  Naman Ojha DC | 14 | 377 | 42 |
| 9 |  Subramaniam Badrinath CSK | 16 | 356 | 41 |
| 10 |  Matthew Hayden CSK | 16 | 346 | 37 |
| 11 |  Murali Vijay CSK | 15 | 458 | 36 |
| 12 |  Rohit Sharma MI | 16 | 404 | 36 |
| 13 |  Andrew Symonds DCH | 16 | 429 | 35 |
| 14 |  Rahul Dravid RCB | 16 | 256 | 34 |
| 15 |  Ambati Rayudu CSK | 14 | 356 | 34 |