| R | Player | Match | Runs | 4s |
|---|---|---|---|---|
| 1 |  James Vince HAM | 16 | 678 | 76 |
| 2 |  Shan Masood DER | 14 | 547 | 63 |
| 3 |  Adam Lyth YOR | 16 | 525 | 59 |
| 4 |  Ben Duckett NOT | 14 | 396 | 52 |
| 5 |  Wayne Madsen DER | 15 | 499 | 52 |
| 6 |  Rilee Rossouw SOM | 16 | 623 | 50 |
| 7 |  Michael Pepper ESS | 14 | 439 | 47 |
| 8 |  Philip Salt LAN | 14 | 390 | 47 |
| 9 |  Chris Lynn NOR | 11 | 516 | 45 |
| 10 |  Stephen Eskinazi MID | 14 | 431 | 44 |
| 11 |  Will Jacks SUR | 15 | 449 | 44 |
| 12 |  Sam Northeast GLA | 14 | 510 | 42 |
| 13 |  Steven Croft LAN | 17 | 548 | 42 |
| 14 |  Colin Ackermann LEI | 14 | 367 | 41 |
| 15 |  Adam Hose WAS | 15 | 557 | 40 |